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KMID : 0379520030190040259
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한국독성학회지
2003 Volume.19 No. 4 p.259 ~ p.266
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Four Weeks Repeated Toxicity Study of 2-o-Benzoylcinnamaldehyde(CB-PH) by Oral Administration in Sprague-Dawley Rats
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Cho Hyun-Mo
Seong Nak-Won
Che Jung-Hwan
Park Ki-Dae
Nam Ki-Taek
Cho Wan-Seob
Han Beom-Seok
Yang Ki-Hwa
Kim Bang-Hyun
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Abstract
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Although ’Cinnamon’ has been widely used for the food and biophamacy in the world, it’s toxicity was not screened completely. Major component of ’cinnamon’ is CB-OH and CB-PH. CB-PH has been reported to have antimutagenic effect. To investigate the toxicity of 2-o-Benzoylcinnama-Idehyde (CB-PH), repeated dose (4 weeks) oral toxicity test performed in SD rats. Results of repeated dose oral toxicity tests for 4 weeks (CB-PH; 500, 1000, 2000 mg/kg/day) suggested that the CB-PH treated group showed no significant toxicological findings with body weights, organ weights, hematological and histopathological findings. Therefore, these data indicated that the maximum tolerated dose of CB-PH was 2000 mg above/kg/day in the rats.
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KEYWORD
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CB-PH, Repeated dose toxicity, Rats
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